Mild traumatic brain injury as a pathological process

Traumatic brain injury (TBI) is defined as dysfunction or other evidence of pathology caused by external physical force. More than 69 million new cases TBI are registered worldwide each year, 80% them - mild TBI. Based on the mechanism induced trauma, we can separate its pathophysiology into primary and secondary injuries. Many literature sources have confirmed that mechanically initiates ionic, metabolic, inflammatory, neurovascular changes in CNS, which lead to acute, subacute, chronic neurological consequences. Despite global nature disease, high heterogeneity, lack a unified classification system, rapid fluctuation epidemiological trends, variability long-term consequences significantly complicate research development therapeutic strategies. In this review paper, systematize current knowledge biomechanical molecular mechanisms provide general information epidemiology complex disorder.